The mechanisms of bone resorption by odontogenic jaw tumor and cyst; analyses of osteoclast formation

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592986
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Osaka University
• Principal Investigator: AIKAWA TOMONAO 大阪大学, 歯学部附属病院, 講師 (00362674)
• Co-Investigator(Kenkyū-buntansha): KIMATA MASAAKI 大阪大学, 歯学部附属病院, 医員 (90448134) ; MIYAGAWA KAZUAKI 大阪大学, 歯学部附属病院, 医員 (50635381)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 顎骨腫瘍 / 骨吸収 / TGF-beta / RANKL

Outline of Final Research Achievements

We have studied the regulation of expression of osteoclast-activating factor, RANKL, in stromal fibroblasts, and mechanisms of osteoclast activation by cytokines prduced by odontogenic tumor and cyst, to clarify the mechanisms of jaw bone resorption by odontogenic tumor and cyst.
We found 3 mechanisms as below; 1)TGF-b and IL-1a was possitive in keratocystic odontogenic tumor and ameloblastoma tissue. These cyokines synergistically induced RANKL expression in stromal fibroblasts. 2) TGF-b enhanced promoter activities of human RANKL gene promoter in stromal fibroblasts, but not in osteoblasts. 3) TGF-b induced osteoclast differentiation of osteoclast progenitor cells.

Free Research Field

口腔外科学