Analysis of the tumor cell-cell interaction in oral cancer invasion

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592988
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: SHIMASUE HIROSHI 広島大学, 大学病院, 助教 (40335683)
• Co-Investigator(Kenkyū-buntansha): TOBIUME Kei 広島大学, 大学院医歯薬保健学研究院, 准教授 (40350037) ; HIGASHIKAWA Koichiro 広島大学, 病院, 講師 (80363084) ; KAMATA Nobuyuki 広島大学, 医歯薬保健学研究院, 教授 (70242211)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 癌の浸潤 / EMT / 扁平上皮癌 / 口腔癌

Outline of Final Research Achievements

Oral cancer tissues generally show the invasion mass histopathologically. Various sized the invasion mass consists of canver cells which maintains cell-cell adhesion and progresses their growth into the submucosa. In this study, we invastigated the mechanism that invasion mass forms with EMT-dependent invasion system and non-EMT dependent EMT system via humoral factor. Humoral factors, CCN1(Cyr61) and galectin-1 which we newly found contributeed the interaction between EMT phenotype tumor cells and non-EMT phenotype tumor cells for the forming tumor invasion mass. This mechanism gives a new insight for the understanding of the local invasion of tumor and could come in useful for the blockage of tumor progression.

Free Research Field

癌の分子生物学