Transient receptor potential channel polymorphisms are associated with oral capsaicin perception and expression of burning mouth syndrome

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592994
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: YOSHIZUMI junko 九州大学, 歯学研究科(研究院), 研究員 (40596376)
• Co-Investigator(Kenkyū-buntansha): KIDO A mizuho 佐賀大学, 大学院医学部医学科, 教授 (60253457) ; OYAMA yukiko 九州大学, 歯学研究院, 助教 (70294957)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: TRPV1 / Burning Mouth syndrome / SNPs

Outline of Final Research Achievements

Burning mouth syndrome (BMS) is known as an idiopathic chronic oral mucosal pain　with no identifiable causative lesions. Patients complain of burning pain in oral mucosa, reminiscent of the feeling of having hot chili in the mouth. Capsaicin, the ingredient of hot chili, is known to activate transient receptor potential vanilloid 1 channels (TRPV1).
We explored the frequency of TRPV1 single nucleotide polymorphisms (SNP) and their impact on sensory properties in the oral cavity. The genotype frequency of the SNP (rs8065080) showed significant difference between healthy controls and BMS patients. Interestingly, among the BMS patients, the clinical data: VAS score of their pain intensity and disease duration was significantly different between genotypes. Additionally, capsaicin solution perception were found to be different among the healthy controls. These results might suggest that TRPV1 contribute to the genetic susceptibility to BMS.

Free Research Field

口腔外科学