Study of malignant transformation of oral squamous cell carcinoma under hypoxia environment

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592995
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: MIYAWAKI Akihiko 産業医科大学, 大学病院, 講師 (40200216)
• Co-Investigator(Kenkyū-buntansha): IKEDA Ryuji 鹿児島大学, 医学部・歯学部附属病院, 准教授 (50398278) ; NAKAMURA Norifumi 鹿児島大学, 医歯(薬)学総合研究科, 教授 (60217875) ; HIJIOKA Hiroshi 鹿児島大学, 医学部・歯学部附属病院, 講師 (70305150)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 低酸素環境 / 口腔癌 / 代謝 / メタボローム解析

Outline of Final Research Achievements

We analyzed metabolomics of oral squamous cell carcinoma using HSC-2,HSC-4 cell lines cultivated under normoxia and hypoxia condition. In particular, glycolysis, amino sugars and pentose phosphate pathway were accelerated for both cell lines, but, under hypoxia condition, pentose phosphate pathway was accelerated. We found that hypoxia condition increased the motility and invasiveness of HSC-2, HSC-4 cells and that induced malignant transformation. These findings suggest that metabolic changes under hypoxia environment influence acquisition of malignancy.

Free Research Field

口腔外科学