Localization of serotonin and serotonin transporter during tooth and periodontal tissue formation

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592996
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Osaka Medical College
• Principal Investigator: HIRATA AZUMI 大阪医科大学, 医学部, 講師 (40263587)
• Co-Investigator(Kenkyū-buntansha): UENO Takaaki 大阪医科大学, 医学部, 教授 (60252996) ; MATSUMURA Tatsushi 岡山大学, 大学院医歯薬学総合研究科, 講師 (70432648) ; IMURA Hideto 愛知学院大学, 歯学部, 講師 (10513187)
• Co-Investigator(Renkei-kenkyūsha): SUGAHARA Toshio 愛知学院大学, 歯学部, 客員教授 (10116048)
• Research Collaborator: GOLDBERG Michel Université Paris Descartes, INSERM UMR-S 1124・Biomédicale des Saints Pères, Professeur Emerite
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 歯 / 歯周組織 / セロトニン / セロトニンレセプター / セロトニントランスポーター

Outline of Final Research Achievements

Previous work suggested that serotonin plays an important part in craniofacial development. Here, we assessed the localization of serotonin and serotonin transporter during tooth and periodontal tissue formation. Our studies indicated that 1) Serotonin expressed in the dental tissues in the initial stage. 2) Serotonin transporter expressed in the dental tissues with progression of tooth and periodontal tissue formation. 3) Both serotonin and serotonin transporter localization were observed in dental epithelial cells. These findings suggested that serotonin and serotonin transporter may have important roles during the process of formation of tooth and periodontal tissue.

Free Research Field

口腔解剖学