2014 Fiscal Year Final Research Report
Analysis of molecular mechanism of caldecrin on osteoclastic bone resorption by inflammatory cytokine
| Project/Area Number |
24593004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOMOMURA Akito 明海大学, 歯学部, 教授 (60188810)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | カルデクリン / 炎症性骨吸収 |
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| Outline of Final Research Achievements |
We collected primary cells derived from murine bone marrow. LPS promoted osteoclastic differentiation of primary bone marrow cells after priming activation with RANKL. Caldecrin inhibited this priming step. It suggests that Caldecrin will be valuable theraputic agent for inflammatory diseases associated with bone resorption.
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| Free Research Field |
顎顔面口腔外科・歯科インプラント
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