The study of oral cancer screening by photo imaging

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593019
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: YOSHIDA Kenji 愛知学院大学, 歯学部, 教授 (40183701)
• Co-Investigator(Kenkyū-buntansha): NAKANISHI Hayao 愛知県がんセンター(研究所), 腫瘍病理学, 研究員 (20207830)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 口腔がん / 近赤外(NIR) 蛍光イメージング / VELscope® / スクリーニング / ICG標識抗ヒトpodoplanin抗体

Outline of Final Research Achievements

Oral squamous cell carcinoma is not infrequently overlooked by conventional examination. Recently, light-induced tissue autofluorescence examination has been introduced. Upon illumination by blue light (436 nm), specific components of fluorophores present in the mucosa including flavin adenine dinucleotide and nicotinamide adenine dinucleotide of the cross-linked collagen/elastin fibers emit low-energy light, which is visualized as the autofluorescence image of the mucosa. Malignant transformation is usually associated with increase in the epithelial cell density, which reduces the excitation of collagen fiber, leading to a decrease in the blue-green autofluorescence and darker appearance compared to uninvolved mucosa. This autofluorescence visual imaging such as VELscope® is a widely used. The aim of this study is to investigate about fluorescence imaging method that can assist and improve sensitive and specific detection and monitoring of OSCC.

Free Research Field

口腔外科学