Molecular targeting therapy by targeting mTOR pathway combined with radiation therapy for oral cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593025
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Nagasaki University
• Principal Investigator: TOBITA Takayoshi 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (00336174)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 口腔癌 / 分子標的治療薬 / mTOR

Outline of Final Research Achievements

Although mTOR inhibitors are expected to be options for the treatment of cancers, it is little known about the treatment effects of mTOR inhibitos when combined with radiation therapy. Therefore, we assessed the potential of this combined therapy in vitro. As a result, cell proliferation of three cancer cell lines [Hela cell, cisplatin-resistant cell (RCB1152), and lung squamous carcinoma cell (RCB0444)] was strongly inhibited after irradiation when exposed to mTOR inhibitors in culture.

Free Research Field

口腔外科学