Evidence Based Medicine for Treatment of Oral Cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 24593027
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Osaka University
• Principal Investigator: MASAYA OKURA 大阪大学, 歯学研究科(研究院), 准教授 (10281130)
• Co-Investigator(Renkei-kenkyūsha): OTA Yoshihide 東海大学, 医学部口腔外科, 教授 (60233152) ; KURITA Hiroshi 信州大学, 大学院医学研究科, 教授 (10273103) ; KIRITA Tadaaki 奈良県立医大, 口腔外科, 教授 (70201465) ; UMEDA Masahiro 長崎大学, 大学院医歯薬総合研究科, 教授 (60301280) ; YANAMOTO Souichi 長崎大学, 大学院医歯薬総合研究科, 講師 (10315260) ; OTSURU Mitsunobu 東海大学, 医学部口腔外科, 講師 (60384864)
• Research Collaborator: SUMIOKA Satoshi ; YAMAMOTO NAO ; LEE Atsushi ; SAWAI Natsuko
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 口腔癌 / EBM / 頸部郭清術 / 術後補助療法 / QOL

Outline of Final Research Achievements

For the purpose of establishing a useful scientific basis in Japan for the treatment of oral cancer, it finished the registration of oral cancer in 1211 patients, and advanced clinical, image, pathology, functional data were integrated and analysed. In addition to Osaka University this study was performed in multicenter study partially with Japanese 6 facilities. As a result, risk factors for distant metastasis of oral cancer was identified, and the significance of adjuvant therapies for oral cancer was clarified. Method of atrophy prevention in sternocleidomastoid sparing neck dissection, N0 neck of treatment strategy decision, proposals of new excellent T classification of the mandibular gingiva cancer, and invasion pattern of tongue cancer were demonstrated. These indicates the unique character of the oral cavity cancer in the head and neck cancer, are thought to be useful in the clinical practice.

Free Research Field

口腔外科