Resistance to apoptosis/anoikis and metastatic ability in oral squamous cell carcinoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593037
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Ehime University
• Principal Investigator: HINO Satoshi 愛媛大学, 医学部附属病院, 講師 (90359927)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 口腔癌 / 転移 / アポトーシス

Outline of Final Research Achievements

In order to improve the outcome from oral cancer treatments, we have to pay constant attention to the occult metastases. We focused that the almost cancer cells showed the resistance to apoptosis, and aimed to release these resistance. In this study, we have used oral squamous cell carcinoma cell lines with and without distinct metastatic ability, and revealed the relationship between their apoptosis sensitivity and the metastatic ability. SAS cells which have no metastatic potency showed modest sensitivity to TRAIL, whereas SAS-T5 cells and SAS-L1 cells, a clone with high metastatic potential showed robust resistance. We found that the mechanisms underlying the differences in these resistance to TRAIL was an activity of Src kinase and the basal levels of A20 expression.

Free Research Field

口腔癌