2014 Fiscal Year Final Research Report
Development of novel therapy for oral cancer through control of microRNA
| Project/Area Number |
24593038
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUNIYASU Hiroki 奈良県立医科大学, 医学部, 教授 (00253055)
KIRITA Tadaaki 奈良県立医科大学, 医学部, 教授 (70201465)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | マイクロRNA / 口腔がん / 化学療法 / 癌幹細胞 |
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| Outline of Final Research Achievements |
miRNAs closely related to the factors influencing the development and the progression of oral squamous cell carcinoma such as epithelial-mesenchymal transition, food ingredients and oxidative stress were extracted. In miR-29b, miR-494 and miR-21 extracted, the target genes of them were identified and the mechanism of their actions was analyzed. Although the mechanism was not clarified enough to report in the period of research, the on-going experiments using culture cells and animal models are expected to lead to the novel strategy in future by targeting these miRNAs and in combination with chemotherapy and radiotherapy.
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| Free Research Field |
外科系歯学
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