2014 Fiscal Year Final Research Report
Establishment of the oral cancer metastasis prediction marker with expression of miRNA analysis
| Project/Area Number |
24593039
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KONDO Seiji 昭和大学, 歯学部, 准教授 (10432634)
MUKUDAI Yoshiki 昭和大学, 歯学部, 助教 (50325099)
YOSHIBA Sayaka 昭和大学, 歯学部, 助教 (60555358)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 口腔癌 / miRNA / microarray analysis / 転移予測マーカー |
|---|
| Outline of Final Research Achievements |
In this study, we regarded miRNA as a metastasis prediction factor of oral cancer and cyclopaedically analyze was done in normal oral mucosa, oral cancer and metastasis tissues. As a result of microarray analysis, the expression of twelve miRNAs were increased and eleven miRNAs were decrease.While only non-significant differential expression of these miRNAs between oral cancer tissue and metastatic tissue was recognized, a tendency differential expression was recognizd.
Oral cancer cells proliferation were accelerated by These miRNAs introduce into the cells but the cells metastatic potential were not accelerated.
|
| Free Research Field |
口腔外科
|
