2014 Fiscal Year Final Research Report
Acid sensitive ion channel in postoperative pain
| Project/Area Number |
24593047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
KIDO Kanta 東北大学, 大学病院, 助教 (40343032)
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| Co-Investigator(Kenkyū-buntansha) |
MASAKI Eiji 東北大学, 大学院歯学研究科, 教授 (40221577)
OHTANT Norimasa 東北大学, 大学院歯学研究科, 非常勤講師 (60338879)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 術後痛 / 酸感受性イオンチャネル |
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| Outline of Final Research Achievements |
We are focusing on the mechanism underlying postoperative pain status. In this study, we examined whether pH changes in wound effect on the sensitization of primary afferents and increase post operative pain using rat behavioral testing and in vitro muscle-nerve preparation. We demonstrated that acid sensitive ion channel is one of the most important factors of postoperative pain in deep tissue.
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| Free Research Field |
歯科麻酔学
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