2014 Fiscal Year Final Research Report
The development of stealth-typed midazolam-encapsulating nano drug carrier for oral administration
| Project/Area Number |
24593055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
MIYAWAKI Takuya 岡山大学, 医歯(薬)学総合研究科, 教授 (00219825)
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| Co-Investigator(Renkei-kenkyūsha) |
YASUDA Tatsuji 岡山大学, 名誉教授 (30092357)
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| Research Collaborator |
TOMOYASU Yumiko
MORI Megumi
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 歯学 / 薬理学 |
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| Outline of Final Research Achievements |
We developed a drug carrier for oral administration of intravenous drugs. We produced the pegylated and miniaturized midazolam-encapsulating liposome as a stealth-typed nano drug carrier in order to improve the bioavailability of midazolam. We orally gave them to rabbits and confirmed the effect of the pegylated and miniaturized midazolam-encapsulating liposomes on the bioavailability of midazolam. The results showed that the pegylated and miniaturized midazolam-encapsulating liposomes increased the bioavailability of midazolam orally administrated.
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| Free Research Field |
歯科麻酔学
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