Development of the dental pulp stem cell differentiation derivative method using GDF-5

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593078
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Iwate Medical University (2014); Tohoku University (2012-2013)
• Principal Investigator: MARUYA Yuriko 岩手医科大学, 歯学部, 講師 (60400389)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Takashi 東北大学, 歯学研究科, 准教授 (90585324) ; IWAMOTO Tsutomu 徳島大学, ヘルスバイオサイエンス研究部, 教授 (90346916)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 歯の再生 / 骨形成因子

Outline of Final Research Achievements

Growth/Differentiation Factor-5 (GDF-5) is a member of the bone morphogenetic protein and promotes formation of bones and cartilages. It has been reported that GDF-5 gene is expressed in oral region. However, the roles of GDF-5 in the differentiation of dental pulp cells are unknown. Thus, we investigated the effect of GDF-5 on the differentiation of dental pulp stem cell.
GDF-5 promoted production of molecules characteristic for odontoblastic phenotype.And gene expression of VEGF increased in the presence of GDF-5. These findings suggested that GDF-5 promotes differentiation of dental pulp stem cell to odontblast.In addition, possibility to become the effective molecules in reproducing pulp tissue from dental pulp stem cell was suggested .

Free Research Field

小児歯科