mitochondria dynamics and craniofacial development

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593096
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Kyushu University
• Principal Investigator: MASUDA Keiji 九州大学, 大学病院, 講師 (60392122)
• Co-Investigator(Kenkyū-buntansha): YAMAZA Haruyoshi 九州大学, 歯学研究院小児口腔医学分野, 講師 (30336151) ; OGASAWARA Takako 九州大学病院, 小児歯科・スペシャルニーズ歯科, 助教 (70596387)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ミトコンドリアダイナミクス

Outline of Final Research Achievements

The purpose of this research is to clarify the role of mitochondria on craniofacial development. Tooth development is one of important issues in this field. We used mouse organ culture system to investigate the role of mitochondria fission factor, Drp1, on the tooth development. The first branchial arch of mouse was cultured under the condition of Drp1 gene knock down by siRNA. The tissue section of cultured organ showed that tooth germ developed into the cap stage irrespective of Drp1 gene knock down, suggesting no essential role of Drp1 on the early stage of tooth development. For further analysis of Drp1 function in tooth development, we plan to investigate the role of Drp1 on the late stage of tooth development, such as enamel and dentin formation.

Free Research Field

小児歯科学