2015 Fiscal Year Final Research Report
Effect of hyperglycemia on root resorption
Project/Area Number |
24593097
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthodontic/Pediatric dentistry
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Research Institution | Nagasaki University |
Principal Investigator |
HOTOKEZAKA Hitoshi 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (90199513)
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Co-Investigator(Kenkyū-buntansha) |
YOSHIMATSU Masako 長崎大学, 病院(歯学系), 助教 (20420630)
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Co-Investigator(Renkei-kenkyūsha) |
TANAKA Motohiro 長崎大学, 工学研究科, 客員研究員 (90420629)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Keywords | 糖尿病 / 生活習慣病 / 矯正治療 / 歯の移動 / 歯根吸収 |
Outline of Final Research Achievements |
The aim of this study was to investigate the effects of diabetes on orthodontic tooth movement and orthodontically induced root resorption in rats. 10-week-old male Sprague-Dawley rats divided into control , diabetes, and diabetes + insulin groups. Diabetes was induced by an injection of streptozotocin. A Ni-Ti closed-coil spring of 10 g was applied for 2 weeks to the maxillary left first molar in all rats to induce mesial tooth movement. Tooth movement was measured using micro-CT images. To quantify the root resorption, the surfaces of the roots of the first molar were analyzed using both scanning electron microscopy and scanning laser microscopy. Diabetes significantly reduced orthodontic tooth movement and orthodontically induced root resorption in rats. The regulation of blood glucose level through insulin administration largely reduced these abnormal responses to orthodontic force application.
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Free Research Field |
歯科矯正学
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