Association between neuropeptide, gastrointestinal activity and the sleep bruxism.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593102
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: University of Miyazaki
• Principal Investigator: NAGATA Junko 宮崎大学, 医学部, 講師 (50264429)
• Co-Investigator(Kenkyū-buntansha): YOSHIOKA Izumi 九州歯科大学, 歯学部, 教授 (10305823) ; YOSHIDA Maho 宮崎大学, 医学部, 医員 (10535785) ; NOMURA Kaori 宮崎大学, 医学部, 医員 (60626141) ; MATSUMOTO Nobuhiro 宮崎大学, 医学部, 助教 (70418838)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 睡眠時ブラキシズム / ペプチド / 消化管運動 / 自律神経 / 睡眠時無呼吸 / 小下顎症

Outline of Final Research Achievements

The purpose of this study is to examine the relationships of neuropeptide to upper digestive tract function, autonomic nervous activity, and sleep bruxism. Cross sectional and Prospective Study were conducted with 15 patients with sleep apnea syndrome (OSAS), 9 patients with sleep bruxism, 5 microgenia patients, and 9 normal subjects.
The OSAS, bruxism, and microgenia patients suggested by significantly higher degree of the Tmax of the 13C-acetate breath test, the arousal index, the LF/HF ratio and the irregularity of gastrointestinal activity rhythm, than for the normal occlusion subjects. The relation between bruxism and neuropeptide and hormones such as cortisol, ghrelin, leptin, oxytocin were suggested. The bruxism episode decreased after treatment of each primary disease.

Free Research Field

歯科口腔外科