The changing of basal membrane during medial edge epithelium disappearing in palatal fusion

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593116
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Fukuoka Dental College
• Principal Investigator: OKA KYOKO 福岡歯科大学, 歯学部, 准教授 (60452778)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 口蓋発生 / TGF-beta / 口蓋上皮

Outline of Final Research Achievements

To clarify the mechanism of cleft palate, we studied about palatal development of mice embryo using histological analysis. We focused on disappearing process of medial edge epithelium (MEE) during palatal shelves fusion. The intra-cellular signaling of TGF-beta which is critical factor for disappearing of MEE, were different between hard and soft region of palatal shelves. Furthermore, Tenascin C expression in palatal mesenchyme induced after basal membrane changing during MEE disappearing, was regulated by TGF-beta signalind, and specially observed in soft palate region. Our data suggested that the extra cellular matrix expression in palatal mesenchyme was differentially regulated by TGF-beta signaling between anterior and posterior of MEE.

Free Research Field

発生学