Elevated expression of Alzheimer disease related genes in periodontiti-affected gingival tissues

2015 Fiscal Year Final Research Report

• Project/Area Number: 24593119
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: Kubota Takehiko 新潟大学, 医歯学総合病院, 講師 (50303136)
• Co-Investigator(Kenkyū-buntansha): MARIYAMA SATOSHI 新潟大学, 医歯学総合病院, 講師 (30397161)
• Co-Investigator(Renkei-kenkyūsha): NOUNO KANAME 新潟大学, 医歯学系, 助教 (80422608)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 医療・福祉 / 歯学 / 免疫学 / 病理学 / 遺伝子発現 / タンパク質局在 / 歯周病 / アルツハイマー病

Outline of Final Research Achievements

We have first reported that the significantly elevated expression of Amyloid beta (A4) precursor protein (APP) transcript levels in human periodontitis-affected gingival tissues. It was also identified that the APP-expressing cells in inflamed gingival tissues were mainly macrophages (Archs Oral Biol 2014). Secondary, significantly upregulated genes including MD-2, CD14, IL-1beta, IL-8 and CXCL-9, which belongs to toll-like receptor (TLR) signaling pathway were also found in periodontitis-affected gingival tissues. It was reported and published in Opn J Stomatol 2014.

Free Research Field

歯周病学