Basic study on the regulation of inflammation of periodontal tissue by targeting Toll-like receptor 4

2015 Fiscal Year Final Research Report

• Project/Area Number: 24593126
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Nagasaki University
• Principal Investigator: YOSHIMURA Atsutoshi 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (70253680)
• Co-Investigator(Kenkyū-buntansha): KANEKO Takashi 福岡歯科大学, 口腔医療センター, 教授 (10284697) ; HARA Yoshitaka 長崎大学, 大学院医歯薬学総合研究科(歯学系), 教授 (60159100)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 歯周炎 / 歯肉縁下プラーク / 歯肉縁上プラーク / Toll-like receptor 4 / Toll-like receptor 2 / 炎症性サイトカイン

Outline of Final Research Achievements

Bacterial components in dental plaque activate innate immune system via receptors, such as Toll-like receptors (TLRs). To control the inflammatory responses in periodontal tissue, we analyzed TLR2- and TLR4-stimulating ability of supra- and subgingival plaque. We found that proinflammatory cytokine production by peripheral blood mononuclear leukocytes is mainly mediated by TLR4.
Controlling TLR4-stiulating ability of supra- and subgingival plaque might be useful for preventing the progression of periodontal diseases.

Free Research Field

歯周病学