Obesity, chronic inflammation and gene-environment interaction: common pathological basis of oral and metabolic diseases

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593148
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Osaka University
• Principal Investigator: OJIMA MIKI 大阪大学, 歯学研究科(研究院), 助教 (20263303)
• Co-Investigator(Kenkyū-buntansha): KUBONIWA Masae 大阪大学, 歯学部附属病院, 講師 (00303983) ; NAGATA Hideki 大阪大学, 大学院歯学研究科, 准教授 (50260641)
• Co-Investigator(Renkei-kenkyūsha): HANIOKA Takashi 福岡歯科大学, 口腔歯学部, 教授 (00144501)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 歯学 / 肥満 / メタボリックシンドローム / 齲蝕 / 歯周病 / 歯の補綴

Outline of Final Research Achievements

Although increasing epidemiological evidence linking poor oral health and systemic conditions has been presented, underlying mechanisms in the relationship remain unclear. The present study aimed to construct a dental-medical linkage database of health checkup records, and to evaluate the relationship of dental caries, periodontal condition, number of teeth and prosthetic condition with metabolism biomarkers and medical findings using multivariate logistic regression models. We found several oral-systemic relationships: prosthetic status and hypertension, and medical finding in gastrointestinal legions, decayed teeth and metabolic syndrome, and obesity, periodontal condition and fatty liver in non-drinkers, polymicrobial infection with major periodontal pathogens and serum lipid profile.

Free Research Field

予防歯科学