2014 Fiscal Year Final Research Report
A trial of establishment of synbiotics and biogenics for the prevention of oral infection
| Project/Area Number |
24593173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | プロバイオティクス / シンバイオティクス / バイオジェニクス |
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| Outline of Final Research Achievements |
For improvement of human oral health environment and disease prevention without using medicine and chemicals, a basic research to create the "synbiotics" which is fusion of probiotics and prebiothics, and "biogenics" using active ingredient was performed.
Although lactobacilli could grow with three kinds of sugar, dental cariogenic bacteria and oral candidiagenic fungus could not be multiplied; therefore it was indicated that those were desirable as prebiotics. Five strains were selected as probiotics candidates, which suppressed the cariogenic bacteria, periodontal bacteria, and oral candidiagenic fungus in common. Active ingredients against the periodontal bacillus were refined from the culture supernatant of two lactobacilli strains, and a possibility was suggested that one major effective component was lactic acid and the other was a low molecular weight substance which did not depend on lactic acid.
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| Free Research Field |
口腔微生物学
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