Development of ozone gel for medicine on preventing and/or treating periodontal disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593179
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Osaka Dental University
• Principal Investigator: OH Hourei 大阪歯科大学, 歯学部, 教授 (20213613)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: オゾン ジェル / 歯周疾患 / 歯周病治療薬 / 抗炎症作用 / 止血作用 / 口臭抑制薬 / 細胞増殖能

Outline of Final Research Achievements

Currently, ozone is being discussed in dentistry as a possible alternative oral antiseptic agent. We have developed the ozone gel which is a glycerin solution containing ozone. The advantages of ozone gel include its long sterilization effect and a lack of an unpleasant smell, as well as the fact that it does not induce resistance in bacteria. In this study, we evaluated the safety of ozone gel in the treatment of oral mucosa irritation as well as its effects on hemostasis and antimicrobial effects. we revealed that ozone gel was very mild to the oral mucosa. The hemostatic ability of ozone gel was almost equal to the Bosmin solution and Liquid Thrombin. The instantaneous antibacterial effect of ozone gel was observed.

Free Research Field

臨床薬理学