Whole body imaging of 123I-oxLDL distribution in mouse with high resolution SPECT system

2014 Fiscal Year Final Research Report

• Project/Area Number: 24601021
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 医学物理学・放射線技術学
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: NAKANO Atsushi 独立行政法人国立循環器病研究センター, 研究所, 研究員 (90217787)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 小動物イメージング / 酸化LDL / 動脈硬化 / RI標識法 / 褐色脂肪組織 / SPECT

Outline of Final Research Achievements

The oxidized low-density lipoprotein (oxLDL) is involved in vascular endothelial dysfunction, injury and inflammation, and plays a key role in atherogenesis and also related to various cardiovascular dieses. The clearance of oxLDL were studied in middle of 1970’s using RAT, monkey and human. These studies suggested the applied oxLDL rapidly accumulated to liver and cleared from blood in several minutes.
However, the CVD (such as stroke, hart dieses) were strongly related to the micro dose oxLDL in blood. We think, the clearance mechanism may be were breakdown in CVD. We investigated the oxLDL metabolism/distribution of mouse whole body imaging with high resolution SPECT system and found that not only the liver but also many organs including brown fat were involved in oxLDL metabolism.

Free Research Field

生理学、画像処理、薬理学、流体力学