Analysis of dynamical behavior of cell- ECM interaction related to tissue sclerosises diseases

2014 Fiscal Year Final Research Report

• Project/Area Number: 24604001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Mechanobiology
• Research Institution: 社会医療法人社団蛍水会名戸ヶ谷病院（ロコモティブシンドローム研究所メカノメディス (2014); Tokyo Institute of Technology (2012-2013)
• Principal Investigator: HARADA Ichiro 社会医療法人社団蛍水会名戸ヶ谷病院(ロコモティブシンドローム研究所メカノメディス, メカノメディスン部門, 主任研究員 (00361759)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 細胞外マトリクス / メカノトランスダクション / 弾性材料 / 物性評価

Outline of Final Research Achievements

Recently, a number of studies suggested stiffness of tissue affect many of the diseases such as malignant alteration of cancer and heart remodeling. Most of the cells adhere to the extracellular matirices effected by its elasticity and those sensing process has been focused as a new type of mechanotransduction. Because many of similarities can be concerned between this mechanotransduction and stimuli of mechanical stress via external forces, similar molecular mechanisms have been proposed as mechanosensing. However, those approaches are shown as transient and immediate molecular processes that how cellular functions or signaling profiles altered in longer-term on soft or stiff substrate is still open question. In this study, we focused on cellular signaling profile which varies in longer-term and propose mechanism a key function involves in sclerosis diseases.

Free Research Field

細胞生物物理学