A role of UHRF1 in establishment and maintenance of genomic imprinting

2014 Fiscal Year Final Research Report

• Project/Area Number: 24613005
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: epigenetics
• Research Institution: Kyushu University
• Principal Investigator: UNOKI MOTOKO 九州大学, 生体防御医学研究所, 助教 (30525374)
• Research Collaborator: MAENOHARA Shoji 九州大学, 生体防御医学研究所 ; OHISHI Hiroaki 九州大学, 生体防御医学研究所 ; TANAKA Tomohiro 九州大学, 医学部生命科学科
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: DNAメチル化 / ゲノムインプリンティング / UHRF1 / 発生 / 生殖細胞

Outline of Final Research Achievements

Genomic imprinting is the epigenetic phenomenon by which certain genes are expressed in a parent-of-origin-specific manner based on imprinted information such as DNA methylation and/or histone modifications established during gametogenesis. Abnormal genomic imprinting can cause human congenital disorders. In this research, we examined whether UHRF1, which is one of important epigenetic regulators, has a role in establishment and/or maintenance of genomic imprinting, and found that UHRF1 is not involved in establishment of genomic imprinting during oogenesis, but has a critical role in maintenance of it during pre-implantation development against global DNA demethylation.

Free Research Field

エピジェネティクス