Development of Cell Tracking System in nonhuman primates

2014 Fiscal Year Final Research Report

• Project/Area Number: 24615009
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Regenerative medicine
• Research Institution: 独立行政法人医薬基盤研究所
• Principal Investigator: AGEYAMA Naohide 独立行政法人医薬基盤研究所, 霊長類医科学研究センター, 主任研究員 (50399458)
• Research Collaborator: FUJISHIRO Yasuyo
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 霊長類 / MRI / 幹細胞 / 再生医療 / 細胞動態 / 磁性体 / 疾患モデル / 移植

Outline of Final Research Achievements

Regenerative medicine based on stem cell transplantation is used to treat various conditions such as ischemia and spinal cord injury. In basic studies using small laboratory animals, transplanted cells improve blood flow at infarcted regions, and reconstruct an injured spinal cord and provide motor ability, though some adverse event reports. Therefore, evaluation systems are necessary to evaluate the safety and efficacy of regenerative medicine using large animals. We developed cell-tracking system in a nonhuman primate model to evaluate the safety and efficacy of regenerative medicine. We could reveal the process of labeling with FIP in cells by fluorescent microscopy. Several organs of cynomolgus monkeys emitted MRI signals from the FIP-labeled cells. The cell-tracking system with transplantation of FIP-labeled MSC in nonhuman primates was safe and efficient rather than any other method of regenerative medicine assessment.

Free Research Field

循環器内科