Ion characterization using energy-resolved ion-mobility tandem mass spectrometry

2017 Fiscal Year Final Research Report

• Project/Area Number: 24619011
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: オミクス計測科学
• Research Institution: Tokyo Institute of Technology (2015-2017); The Institute of Physical and Chemical Research (2012-2014)
• Principal Investigator: Hongo Yayoi 東京工業大学, 地球生命研究所, 研究員 (40435681)
• Project Period (FY): 2012-04-01 – 2018-03-31
• Keywords: 質量分析 / 分子構造解析 / イオン反応

Outline of Final Research Achievements

New molecular structural characterization technique using an energy-resolved ion-mobility mass spectrometry (ER-IMS-MSn) was developed in the period. Data mining for the relationship between stability of the gas phase ion structures and ER-IMS MSn spectra was used to elucidate the structural characterization of cyclic molecules,such as depsipeptides. Ion isomerization during the collision activation experiments was obvious for relatively stable alkaline metal addition ions. So that, alkaline addition ions were suitable for the ion structural characterization.This technique enabled us to obtain additional structure information using mass spectrometry.

Free Research Field

分析化学