Influence of microgravity environment on skeletal muscle of zebrafish

2014 Fiscal Year Final Research Report

• Project/Area Number: 24620005
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 宇宙生命学
• Research Institution: Kyoto University
• Principal Investigator: SATO Fuminori 京都大学, 健康長寿社会の総合医療開発ユニット, 特定助教 (10588263)
• Co-Investigator(Kenkyū-buntansha): SEHARA Atsuko 京都大学, 再生医科学研究所, 教授 (60209038)
• Co-Investigator(Renkei-kenkyūsha): KAWAKAMI Koichi 国立遺伝学研究所, 教授 (70195048) ; SUZUKI Yutaka 東京大学, 新領域創成科学研究科, 教授 (40323646)
• Research Collaborator: UCHIDA Satoko ; TANIGAKI Fumiaki
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 微重力環境 / ゼブラフィッシュ / 骨格筋 / トランスクリプトーム解析

Outline of Final Research Achievements

We performed space stay experiments using zebrafish which are aquatic organisms for analyzing microgravity environment-dependent skeletal muscle atrophy. As a results of transcriptome analysis (comprehensive analysis of gene expression) using a next-generation sequencing, the variation was detected in a number of gene expression in skeletal muscle of space stay zebrafish. This result indicates that the skeletal muscle of zebrafish is affected by microgravity environment similar to that of terrestrial animals. Compared with the variation of gene expression on movement suppression and aging which are generally known to induce skeletal muscle atrophy, there are many differences in variation of gene expression on microgravity environment.

Free Research Field

発生生物学　分子生物学