The prospective study of nigrostriatal dopaminergic function using by FMT-PET in patients with REM sleep behavior disorder

2014 Fiscal Year Final Research Report

• Project/Area Number: 24621009
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 睡眠科学
• Research Institution: Dokkyo Medical University
• Principal Investigator: MIYAMOTO Masayuki 獨協医科大学, 医学部, 教授 (00265331)
• Co-Investigator(Kenkyū-buntansha): MIYAMOTO Tomoyuki 獨協医科大学越谷病院, 神経内科, 教授 (40296174)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: レム睡眠行動異常症 / 黒質線条体ドパミン神経 / FMT-PET / 経年変化 / パーキンソン病 / レビー小体関連疾患

Outline of Final Research Achievements

In recent studies, Some REM sleep behavior disorder (RBD) patients reported an increased risk to develop Parkinson's disease (PD). We prospectively assessed a nigrostriatal dopaminergic function using by FMT-PET in patients with idiopathic RBD (IRBD) and compared the finding with healthy controls at baseline and after 1.3 to 5.3 years. At baseline, there are a lot of individual variation in FMT uptake in putamen in IRBD. IRBD patients, who developed PD in the follow up period, reduced putaminal FMT uptake at baseline. However, in this study, reduction rate of putaminal FMT uptake was not associated with constipation, olfactory dysfunction or impaired color discrimination. Further prospective follow up study of this RBD cohort is needed to clarify predictors of pathological neurodegenerative process of nigrostriatal dopaminergic neurons and be useful in studies of potential disease-modifying therapy in these patients.

Free Research Field

睡眠科学