2013 Fiscal Year Final Research Report
Roles of proteasome-dependent protein degradation in updating memory
| Project/Area Number |
24650172
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
KIDA Satoshi 東京農業大学, 応用生物科学部, 教授 (80301547)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 神経科学 / 脳・神経 / 記憶再固定化 / 記憶消去 / 記憶想起 / 記憶アップデート / タンパク質分解 / 記憶固定化 |
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| Research Abstract |
In this study, we tried to understand molecular mechanisms by which memory is updated. To do this, we examined roles of proteasome-dependent protein degradation in process such as memory reconsolidation and extinction, both of which are models of updating memory, using several memory tasks in mice. We found that proteasome-dependent protein degradation is activated when retrieved memory is reconsolidated, enhanced or extinguished. In contrast, this protein degradation was not activated when memory is initially consolidated. Furthermore, the inhibition of proteasome-dependent degradation using drugs blocked destabilization, enhancement and extinction of retrieved memory. Taken together, our observations suggest that activation of proteasome-dependent protein degradation is required for update (modification) of existing memory. It is possible that proteasome-dependent protein degradation is an useful molecular marker of updating memory.
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[Journal Article] Roles of CREB in the regulation of FMRP by group I metabotropic glutamate receptors in cingulate cortex2012
Author(s)
Wang, H., Morishita, Y., Miura, D., Naranjo, J.R., Kida, S. & Zhuo, M.
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Journal Title
Mol. Brain
Volume: 5
Pages: 27
DOI
Peer Reviewed
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[Journal Article] Enhancement of fear memory by retrieval through reconsolidation
Author(s)
Fukushima, H., Zhang, Y., Archbol, G., Ishikawa, R., Nader, K. Kida, S.
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Journal Title
Peer Reviewed
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[Journal Article] Time-dependent enhancement of hippocampus-dependent memory after treatment with memantine : implications for enhanced hippocampal adult neurogenesis
Author(s)
Ishikawa, R., Kim, R., Namba, T., Kohsaka, S., Uchino, S. & Kida, S.
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Journal Title
Hippocampus
Volume: (in press)
DOI
Peer Reviewed
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