Examination of angiogenic potential of brain-derived injury-induced neural stem cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24650173
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neuroscience in general
• Research Institution: Hyogo Medical University
• Principal Investigator: NAKAGOMI Takayuki 兵庫医科大学, 医学部, 准教授 (80434950)
• Co-Investigator(Renkei-kenkyūsha): MATSUYAMA Tomohiro 兵庫医科大学, 医学部, 教授 (10219529) ; TAGUCHI Akihiko (財)先端医療振興財団, 研究部, 部長 (10359276) ; SOMA Toshihiro 兵庫医科大学, 医学部, 准教授 (40273619)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 神経再生 / 血管新生 / 神経幹細胞 / 多能性幹細胞 / 脳梗塞 / 虚血

Outline of Final Research Achievements

In the present study, we investigated whether injury-induced neural stem/progenitor cells (iNSPCs) that are induced following ischemic stroke have the multipotency to differentiate into vascular cells as well as neural cells. We found that iNSPCs acquire multipotential stem cell activity following ischemic stroke and differentiate into both neural and vascular cells under certain conditions. These findings strongly suggest that neurogenesis and vasculogenesis can occur simultaneously. In addition, this indicates that iNSPCs play an important role in neurovasculogenesis under brain injuries, such as ischemic stroke.

Free Research Field

再生医学