2014 Fiscal Year Final Research Report
A novel mechanism to transmit information of extracellular signals to the cytoskeleton
| Project/Area Number |
24650174
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
SHINTANI Takafumi 基礎生物学研究所, 統合神経生物学研究部門, 准教授 (10312208)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 細胞骨格 / APC2 / 細胞移動 / 神経細胞 / 脳 |
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| Outline of Final Research Achievements |
We analyzed Apc2-deficient mice, and found that a lack of Apc2 induces defective lamination in some brain regions, including the cerebral cortex, cerebellum, hippocampus, and olfactory bulb. APC2 is co-distributes with microtubules and actin fibers, and considered to be an essential mediator of the cytoskeletal regulation in response to extracellular signals. We further found that inhibition of APC2 functions on cytoskeleton by LRR is attenuated by a kinase inhibitor. We also generated LRR1- and LRR2-deficient mice.
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| Free Research Field |
神経生物学
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