2013 Fiscal Year Final Research Report
A verification study of oxidized albumin as a risk factor for Alzheimer's disease
| Project/Area Number |
24650187
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Osaka City University |
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Principal Investigator |
YAMAMOTO KEIICHI 大阪市立大学, 医学(系)研究科(研究院), 研究員 (90623257)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | アルツハイマー病 / バイオマーカー / 血液 |
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| Research Abstract |
Regarding decreased excretion of brain amyloid beta (Abeta) in patients with Alzheimer's disease (AD), the applicant focused attention on the fact that 90% of Abeta was bound to albumin in blood and hypothesized that changes in the properties of albumin would result in decreased excretion of Abeta from the brain into the blood.
The blood albumin-Abeta complex in AD patients was measured by enzyme-linked immunosorbent assay (ELISA) to determine whether or not there is a decrease. It was found and reported that AD patients showed lower blood complex levels than the control group and that changes in the properties of albumin were the cause. Regarding the concrete contents of such modification, the applicant initially focused attention on oxidized and reduced albumin, neither of which was increased in AD patients, and the content of modification was thus not clarified during the study period.
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