2013 Fiscal Year Final Research Report
Meningeal immunity as a novel target for treating neurodevelopmental disorders induced by maternal immune activation
| Project/Area Number |
24650190
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
SHIMADA Atsuyoshi 愛知県心身障害者コロニー発達障害研究所, 病理学部, 室長 (50311444)
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| Research Collaborator |
ISHII Sanae , 日本学術振興会特別研究員RPD (40435863)
INABA Muneo 関西医科大学, 医学部, 非常勤講師 (70115947)
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| Project Period (FY) |
2012 – 2013
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| Keywords | 発達障害 / 炎症 / 免疫髄膜 / 脈絡叢自閉症 |
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| Research Abstract |
Maternal inflammation during pregnancy is one of the risk factors for autism in offspring. In the present study using experimental animals, we showed that bone marrow-derived immune cells were stationed in the meningeal space that covered the brain parenchyma. The meningeal immunity played a key role to sense and react to peripheral inflammatory responses, resulting in the activation of brain parenchymal cells. Intracranial immune cells were located to the cephalic mesenchyme (meningeal precursors) during the fetal period, but not to the brain parenchyma. Therefore, we suggest that the effects of maternal inflammation on the fetal brains are induced by the reactions exerted by the cephalic mesenchymal immune cells during pregnancy.
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[Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes2013
Author(s)
Tanisawa K, Mikami E, Fuku N, Honda Y, Honda S, Ohsawa I, Ito M, Endo S, Ihara K, Ohno K, Kishimoto Y, Ishigami A, Maruyama N, Sawabe M, Iseki H, Okazaki Y, Hasegawa-Ishii S, Takei S, Shimada A, Hosokawa M, Mori M, Higuchi K, Takeda T, Higuchi M and Tanaka M
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Journal Title
BMC Genomics
Volume: 14
Pages: 248
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[Journal Article] Selective localization of bone marrow-derived ramified cells in the brain adjacent to the attachments of choroid plexus2013
Author(s)
Hasegawa-Ishii S, Shimada A, Inaba M, Li M, Shi M, Kawamura N, Takei S, Chiba Y, Hosokawa M and Ikehara S
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Journal Title
Brain, Behavior, and Immunity
Volume: 29
Pages: 82-97
DOI
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