2013 Fiscal Year Final Research Report
Regulation of neural stem cell through nervous- and immune-systems cross-talk
| Project/Area Number |
24650198
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kyushu University (2013)
Nara Institute of Science and Technology (2012) |
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Principal Investigator |
NAKASHIMA Kinichi 九州大学, 医学(系)研究科(研究院), 教授 (80302892)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 成体ニューロン新生 / 神経幹細胞 / 自然免疫 |
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| Research Abstract |
It is known that the behavior of adult neural stem cells (aNSC) is strongly influenced by unique microenvironment surrounding aNSCs called niche. Acute epileptic seizures are classically know to be associated with aberrant augmentation of neurogenesis in the dentate gyrus (DG) in the adult hippocampus and migration of newly born neurons to ectopic locations. In this research, we found that TLR9, known as as innate immune receptor, suppress epilepsy-triggered aberrant neurogenesis in the adult mouse DG. Microglia are known to act as inflammatory cells in epileptic conditions. When we inhibited seizure-induced microglial activation in WT mice by minocycline administration, both aberrant augmentation of neurogenesis and ectopic localization of newly generated neurons in the DG were exacerbated. These findings imply that TLR9 signal activation in microglia plays a critical role in the attenuation of epilepsy-triggeres aberrant neurogenesis in the adult mouse DG.
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[Presentation] Brain-region specific developmental alterations in mouse prenatally and postnatally exposed to bisphenol A(BPA)2013
Author(s)
Chai, M., Juliandi, B., Sanosaka, T., Tanemura, K., Igarashi, K., Nakashima, K.
Organizer
NEUROSCIENCE 2013
Place of Presentation
San Diego
Year and Date
20131109-13
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[Presentation] Analysis of mechanisms underlying neurogenesis in the adult hippocampus regulated by hemimethylated DNA recognition factor,Np95/Uhrf12013
Author(s)
Murao, N., Matsuda, T., Koseki, H., Namihira, M., Nakashima, K.
Organizer
NEUROSCIENCE 2013
Place of Presentation
San Diego
Year and Date
20131109-13
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[Presentation] Maintenance DNA methyltransferase DNMT1 controls neuronal differentiation of late-gestational neural stem cells2013
Author(s)
Noguchi, H., Namihira, M., Sanosaka, T., Tsujimura, K., Fukao, Y., Igarashi, K., Kimura, A., Nakashima, K.
Organizer
NEUROSCIENCE 2013
Place of Presentation
San Diego
Year and Date
20131109-13
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[Presentation] TLR9 signaling in microglia suppresses epilepsy-triggered aderrant neurogenesis in the adult hippocampus2013
Author(s)
Matsuda, T., Katano, Y., Adefuin, M, A., Murao, N., Juliandi, B., Kawai, T., Akira, S., Nakashima, K.
Organizer
NEUROSCIENCE 2013
Place of Presentation
San Diego
Year and Date
20131109-13
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