2013 Fiscal Year Final Research Report
Development of a research technique to create animal model of brain lesions using therapeutic linear accelerator
| Project/Area Number |
24650206
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
TANAKA Masaki 北海道大学, 医学研究科, 教授 (90301887)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Masayori 北海道大学, 大学院医学研究科, 教授 (80314772)
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| Research Collaborator |
KUNIMATU Jun 北海道大学, 大学院医学研究科, 助教 (50632395)
MIYAMOTO Naoki 北海道大学, 大学院医学研究科, 助教 (00552879)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 神経科学 / 放射線治療装置 / 大脳皮質 / 霊長類 / 疾患モデル |
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| Research Abstract |
We developed a research technique to create animal model of brain lesions using the therapeutic linear accelerator. A total of four irradiations (130-150 Gy) were performed on the right frontal eye field of three Japanese monkeys. During a few weeks following irradiation, brain edema was evident in MRI and the performance of oculomotor tasks was declined; however, it recovered thereafter. For one monkey that was followed up about 8 months, the behavioral deficits reappeared in the 4th month and gradually progressed. Postmortem histological examination in two animals revealed large necrosis in the white matter and surrounding hemorrhage, but the cortical gray matter retained layers. This technique can be applied to deep brain structures in the future study. We now plan to use lower doses and will follow up longer interval.
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[Presentation] Contribution of the cerebellum to perceptual prediction2013
Author(s)
Matsushima, A., Itoh, S., Yoshida, A., Kurkin, S., Yabe, I., Sasaki, H., Tanaka, M
Place of Presentation
京都国際会館
Year and Date
2013-06-20
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