2013 Fiscal Year Final Research Report
4D Gene Analysis in Functional Neuronal Circuits
| Project/Area Number |
24650216
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Fusional basic brain science
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| Research Institution | Kyoto University |
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Principal Investigator |
WANG Dan Ohtan 京都大学, 物質-細胞統合システム拠点, 助教 (50615482)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Akimitsu (60314233)
SUGI Takuma (70571305)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | イメージング / RNA / 空間分布 / 転写 / 小脳 |
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| Research Abstract |
De novo transcription is required for long-term plasticity and lasting memory formation. We are developing live-cell RNA imaging techniques to visualize RNA dynamics in a living and functional neuronal circuit where memory information is stored. To do so, we have delivered light-on probes into the living mouse cerebella and imaged RNA molecules at single cell level. Curiously, we have observed spatial organization of RNA molecules that are concentrated at specific intranuclear foci. We are currently optimizing the system to apply the imaging method to memory studies.
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Research Products
(17 results)
