2012 Fiscal Year Final Research Report
Detection of circadian rhythms from peripheral blood samples in the diagnosis of diseases of elderly people
| Project/Area Number |
24650217
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fusional basic brain science
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| Research Institution | Kyoto University |
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Principal Investigator |
OKAMURA Hitoshi 京都大学, 大学院・薬学研究科, 教授 (60158813)
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| Project Period (FY) |
2012
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| Keywords | 遺伝子 / 循環器・高血圧 / トランスレーションリサーチ / バイオテクノロジー |
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| Research Abstract |
We established a sensitive method for detecting clock genes at single cell levels in cells derived from human lymphocyte. We collected cells by cell sorter, and RNA isolation and reverse transcription to make cDNA at single step. We have established a method to detect all clock genes at the level of single cells in the peripheral blood.
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Research Products
(7 results)
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[Journal Article] Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm2012
Author(s)
Negoro H, Kanmatsu A, Doi M, Suadicani SO, Matsuo M, Imanura M, Okinami T, Nishikawa N, Oura T, Matsuji S, Seo K, Tainaka M, Urabe S, Kiyokage E, Todo T, Okamura H*, Tabata H, Ogawa O* (*Corresponding authors)
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Journal Title
Nature Communications
Volume: 3
Pages: 809
DOI
Peer Reviewed
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