Detectability of protein concentration changes in MRI

2014 Fiscal Year Final Research Report

• Project/Area Number: 24650246
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Hokkaido University
• Principal Investigator: YAMAMOTO Toru 北海道大学, 保健科学研究院, 教授 (80261361)
• Co-Investigator(Kenkyū-buntansha): TSUTSUMI Kaori 北海道大学, 大学院保健科学研究院, 助教 (80344505) ; THA Khin Khin 北海道大学, 大学院医学研究科, 特任講師 (20451445)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: MRI / タンパク / 誘電率 / 縦緩和 / 横緩和

Outline of Final Research Achievements

To investigate the possibility of noninvasive MR detection of pathologic changes in protein concentration, we measured the protein concentration dependency of permittivity, longitudinal and transverse relaxation rate. The transverse relaxation rate showed most accurate dependency. We also measured the transverse relaxation rate of cerebrospinal fluid in lateral ventricle and showed enough accuracy to detect pathologic―bacterial meningitis etc.―changes of protein concentration by developing a method to derive pixels that are free from cerebrospinal fluid flow.

Free Research Field

磁気共鳴医学