2013 Fiscal Year Final Research Report
Effects of neuromodulator on sub-network structure during perceptual computation
Project/Area Number |
24650252
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Keywords | 聴覚 / 大脳皮質 / 脳 / 同期 / 神経修飾物質 |
Research Abstract |
The objective of the present work was to elucidate how neuromodulator affected formation and/or stability of functional assembly of neural population in the sensory cortex. In particular, we investigated VNS-induced modulation of neural activities in the auditory cortex because VNS activates serotonergic and noradrenergic systems that globally affect the cerebral cortex. Consequently, we demonstrated that VNS modulates the local synchrony of spontaneous cortical activities in a state-dependent manner and that VNS alters the selectivity and time resolution of auditory evoked responses.
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