Development on an innovative oral implant with PDL absorbing percussive force generated by mastication

2013 Fiscal Year Final Research Report

• Project/Area Number: 24650255
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Nagoya University
• Principal Investigator: MORITA Yasuyuki 名古屋大学, 工学(系)研究科(研究院), 准教授 (90380534)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 分化 / 間葉系幹細胞 / 細胞配列 / 機械的伸縮刺激 / 細胞外マトリックス / コラーゲン / タンパク質 / 遺伝子

Research Abstract

The following conclusions were obtained in this project. Appropriate cyclic stretching stimulation definitely promotes differentiation of mesenchymal stem cells. In addition, cultivating cells in a similar environment in vivo is pretty effective for the cellular differentiation and extracellular matrix formation.

Research Products

• [Journal Article] Differences between protein expression and extracellular matrix state on uniaxial stretching for tenogenic differentiation (2014)
  • Author(s): Y. Morita, S. Suzuki, Y. Ju, and N. Kawase.
  • Journal Title: Journal of Mechanics in Medicine and Biology Volume: Vol.14 Pages: 1450025
  • Peer Reviewed
• [Journal Article] In vitro experimental study for the determination of cellular axial strain threshold and preferential axial strain from cell orientation behavior in a non-uniform deformation field (2013)
  • Author(s): Y. Morita, S. Watanabe, Y. Ju, and S. Yamamoto.
  • Journal Title: Cell Biochemistry and Biophysics Volume: Vol.67 Pages: 1249-1259
  • DOI: 10.1007/s12013-013-9643-3
  • Peer Reviewed
• [Journal Article] Evaluation of stem cell-to-tenocyte differentiation using atomic force microscopy to measure cellular elastic moduli (2013)
  • Author(s): Y. Morita, T. Mukai, Y. Ju, and S. Watanabe.
  • Journal Title: Cell Biochemistry and Biophysics Volume: Vol.66 Pages: 73-80
  • DOI: 10.1007/s12013-012-9455-x
  • Peer Reviewed
• [Journal Article] Experimental and numerical investigation on strain distribution in alveolar bone model around dental implant (2012)
  • Author(s): Y. Morita, LM. Ren, and M. Todo.
  • Journal Title: Proceeding of the ISEM-ACEM-SEM-7th ISEM Volume: 12 Pages: M111
  • Peer Reviewed
• [Journal Article] デジタル画像相関法を用いた圧縮試験下でのインプラント周囲骨の変位・ひずみ分布解析 (2012)
  • Author(s): 森田康之
  • Journal Title: 日本口腔インプラント学会誌 Volume: 25巻 Pages: 488-495
  • Peer Reviewed
• [Presentation] 巨陽,細胞外マトリックスの力学場計測の実現に向けたDVC法の開発 (2013)
  • Author(s): 森田康之,河瀬直樹
  • Organizer: 日本非破壊検査協会平成25年第2回応力・ひずみ測定部門講演会
  • Place of Presentation: 金沢大学
  • Year and Date: 2013-11-08
• [Presentation] Experimental study for the relationship between cell differentiation and mechanical strain using a non-uniform deformation field (2013)
  • Author(s): Y. Morita, T. Sato, and Y. Ju.
  • Organizer: The 8th ISEM13-Sendai
  • Place of Presentation: Sendai City War Reconstruction Memorial Hall, Sendai
  • Year and Date: 2013-11-06
• [Presentation] 巨陽,配向を制御した間葉系幹細胞の伸縮培養による腱細胞への分化および評価に関する研究 (2013)
  • Author(s): 森田康之,鈴木敏
  • Organizer: 日本実験力学会2013年度年次講演会
  • Place of Presentation: 由利本荘市文化交流館「カダーレ」
  • Year and Date: 2013-08-22
• [Presentation] Experimental and numerical investigation on strain distribution in alveolar bone model around dental implant (2012)
  • Author(s): Y. Morita, LM. Ren, and M. Todo.
  • Organizer: The ISEM-ACEM-SEM-7th ISEM12
  • Place of Presentation: The Grand Hotel, Taipei, Taiwan
  • Year and Date: 2012-11-09
• [Presentation] Applications of digital image correlation technique to dental biomechanics (2012)
  • Author(s): Y. Morita.
  • Organizer: 2012 IUTAM Symposium on Advances of Optical Methods in Experimental Mechanics
  • Place of Presentation: The Grand Hotel, Taipei, Taiwan
  • Year and Date: 2012-11-05
• [Book] 歯科インプラント・口腔インプラント (2012)
  • Author(s): 森田康之
  • Total Pages: 88-89
  • Publisher: 日本実験力学会