2013 Fiscal Year Final Research Report
Direct manipulation of the intracellular stress distribution for controlling cell division
| Project/Area Number |
24650257
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
NAGAYAMA Kazuaki 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (10359763)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Takeo 名古屋工業大学, 工学研究科, 教授 (30209639)
SUGITA Shukei 名古屋工業大学, 工学研究科, 助教 (20532104)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | バイオメカニクス / 生体・情報計測 / 細胞骨格 / 細胞核 / メカノトランスダクション |
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| Research Abstract |
In this study, we developed a technique to measure the dynamic changes in intracellular stress distribution during cell stretching, and we also established to manipulate intracellular tension. Using these techniques, we investigated the effects of mechanical stimuli, such as cell stretching, on the division and proliferation of HeLa cells. We found that the cell spindle orientation during mitosis dramatically changed following cell stretching in perpendicular to the equator plane of the cells: HeLa cells divided in perpendicular to the stretch direction. These results indicate that cells divide according to mechanical factors provided by the forces applied to the cells. Our technique would be useful in investigating the mechanotransduction mechanisms of dividing cells.
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[Journal Article] Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-212013
Author(s)
Banjo T, Grajcarek J, Yoshino D, Osada H, Miyasaka KY, Kida YS, Ueki Y, Nagayama K, Kawakami K, Matsumoto T, Sato M, Ogura T.
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Journal Title
Nature Communications
Volume: 4
Pages: 1978
Peer Reviewed
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