2013 Fiscal Year Final Research Report
Pacemaking mechanism of human SA node cell using human iPS-derived cardiomyocytes
| Project/Area Number |
24650260
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | University of Fukui (2013)
Kyoto University (2012) |
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Principal Investigator |
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| Research Collaborator |
HIMENO Yukiko 立命館大学, 日本学術振興会, 特別研究員
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | iPS細胞 / ペースメーカー / 数理モデル解析 |
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| Research Abstract |
The purpose of the present study was to clarify pacemaking mechanisms of human cardiac pacemaker cells, SA node cells. In order to achieve the goals, I performed cellular physiological experiments using human iPS-derived cardiomyocytes and mathematical simulations. Several combinations of chemicals enhanced proliferation of human iPS-derived cardiomyocytes, with similar electrophysiological characteristics. Theoretical analyses suggested that coupling of mitochondrial and sarcoplasmic reticulum Ca dynamics is important for pacemaking, and that contribution of mitochondrial Ca transporter is mechanism dependent.
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[Journal Article] Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells2013
Author(s)
Uosaki H, Magadum A, Seo K, Fukushima H, Takeuchi A, Nakagawa Y, Moyes KW, Narazaki G, Kuwahara K, Laflamme M, Matsuoka S, Nakatsuji N, Nakao K, Kwon C, Kass DA, Engel FB, Yamashita JK.
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Journal Title
Circulation : Cardiovascular Genetics
Volume: 6
Pages: 624-633
DOI
Peer Reviewed
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