2013 Fiscal Year Final Research Report
Development of cell surface modification with PEGylated lipid and external stimulation
| Project/Area Number |
24650262
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyoto University |
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Principal Investigator |
HIGUCHI Yuriko 京都大学, 健康長寿社会の総合医療開発ユニット, 講師 (40402797)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Shigeru 長崎大学医歯薬学総合研究科, 医薬品情報学, 教授 (20322307)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 幹細胞 / PEG脂質 / 細胞膜表面修飾 / 超音波 |
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| Research Abstract |
Control of cell function by cell surface modification with functional molecule is a promising way to improve cell therapy. Cell surface modification through the association between cell membrane and PEGylated lipid is suitable for clinical application because PEGylated lipid could be modified on any type of cell and could be modified only by incubating with cells. However, modification efficiency is not high. In this study, ultrasound irradiation or addition of cyclodextrin could improve cell surface modification with PEGylated lipid by inhibiting the formation of PEGyated lipid assembly in the medium.
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