2013 Fiscal Year Final Research Report
Manipulation of high-density lipoprotein structure and function for development of gene delivery carrier
| Project/Area Number |
24650263
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyoto University |
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Principal Investigator |
MURAKAMI Tatsuya 京都大学, 物質-細胞統合システム拠点, 准教授 (90410737)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 遺伝子キャリア / ドラッグデリバリー |
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| Research Abstract |
Our purpose in this study is to develop nanomaterials capable of delivering therapeutic gene to desired sites, such as cancer tissues, by utilizing natural nanomaterials in our body. High-density lipoprotein (HDL) is a natural nanomaterial that delivers lipids from peripheral tissues to the liver in our body. Due to its physiological functions, HDL have a propensity to accumulate in liver via HDL receptor recognition of apoA-I moiety in HDL. In order to weaken this recognition in the liver and then to redirect HDL to desired sites, we designed 9 apoA-I deletion mutants and succeeded in preparation of 8 HDL mutants. Among them, a few HDL mutants were found to show decreased affinity to the HDL receptor.
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Research Products
(25 results)
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[Journal Article] Helicity-selective photoreaction of single-walled carbon nanotubes with organosulfur compounds in the presence of oxygen2013
Author(s)
Maeda, Y.; Higo, J.; Amagai, Y.; Matsui, J.; Ohkubo, K.; Yoshigoe, Y.; Hashimoto, M.; Eguchi, K.; Yamada, M.; Hasegawa, T.; Sato, Y.; Zhou, J.; Lu, J.; Miyashita, T.; Fukuzumi, S.; Murakami, T.; Tohji, K.; Nagase, S.; Akasaka, S.
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Journal Title
Journal of the American Chemical Society
Volume: 135
Pages: 6356-6362
DOI
Peer Reviewed
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[Journal Article] Photodynamic and photothermal effects of semiconducting and metallic-enriched single-walled carbon nanotubes2012
Author(s)
Murakami, T., Nakatsuji, H., Inada, M., Matoba, Y., Umeyama, T., Tsujimoto, M., Isoda, S., Hashida, M., Imahori, H.
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Journal Title
Journal of the American Chemical Society
Volume: 134
Pages: 17862-17865
DOI
Peer Reviewed
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[Journal Article] Cration of pure nanodrugs and their anticancer properties2012
Author(s)
Kasai, H., Murakami, T., Ikuta, Y., Koseki, Y., Baba, K., Oikawa, H., Nakanishi, H., Okada, M., Shoji, M., Ueda, M., Imahori, H., Hashida, M
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Journal Title
Angewandte Chemie International Edition
Volume: 51
Pages: 10315-10318
DOI
Peer Reviewed
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[Journal Article] Utilization of photoinduced charge-separated state of donor-acceptor-linked molecules for regulation of cell membrane potential and ion transport2012
Author(s)
Numata, T., Murakami, T., Kawashima, F., Morone, N., Heuser, J. E., Takano, Y., Ohkubo, K., Fukuzumi, S., Mori, Y., Imahori, H.
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Journal Title
Journal of the American Chemical Society
Volume: 134
Pages: 6092-6095
DOI
Peer Reviewed
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