Development of dental resin adhesives using stimuli-responsively degradable and enamel-adhesive polyrotaxanes for orthodontics

2014 Fiscal Year Final Research Report

• Project/Area Number: 24650274
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NOBUHIKO Yui 東京医科歯科大学, 生体材料工学研究所, 教授 (70182665)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 歯科材料 / ポリロタキサン / 刺激応答性

Outline of Final Research Achievements

Resin monomer-soluble polyrotaxane (PRX) crosslinkers with cleavable end-groups were designed to develop degradable resins for orthodontics. The PRX containing 50 α-cyclodextrins (α-CDs) with disulfide end-groups was modified with n-butyl groups per α-CD molecule was completely soluble in conventional resin monomers such as 2-hydroxyethyl methacrylate (HEMA) and urethane dimethacrylate (UDMA). The synthesized n-butyl-containing PRX was further modified with 2-aminoethyl methacrylate to provide crosslinkable acrylic groups onto PRX. The prepared resin monomer-soluble PRX crosslinker was successfully polymerized with a mixture of HEMA and UDMA to provide photosetting plastic. It was confirmed that the Vickers hardness of the prepared plastic was greatly decreased after treatment with dithiothreitol. This result indicates that the resin monomer-soluble PRX crosslinkers have much potential in applications for degradable photosetting plastics potentially used in orthodontics.

Free Research Field

人間医工学、医用生体工学　生体材料学