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2013 Fiscal Year Final Research Report

Development of a novel charged-particle therapy combined with cisplatin-incorporated polymeric micelles

Research Project

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Project/Area Number 24650287
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Medical systems
Research InstitutionTohoku University

Principal Investigator

TERAKAWA Atsuki  東北大学, 工学(系)研究科(研究院), 准教授 (10250854)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords粒子線治療 / シスプラチン / ナノミセル / PIXE分析
Research Abstract

Therapeutic experiments were performed using a murine solid tumor to develop a novel combined-treatment between proton therapy and cisplatin. The results showed that the proton therapy combined with cisplatin inhibited tumor growth significantly in comparison to their monotherapies. Elemental analysis of the tumor treated with cisplatin-incorporated polymeric micelles (CDDP-micells) was performed to evaluate both concentration of the drug in the tumor tissue using the conventional PIXE analysis and its spatial distribution in the tumor using the submilli-PIXE analysis. The results showed higher drug concentration for the tumor treated with (CDDP-micells) compared to cisplatin whereas no significant difference in the concentration between CDDP-micells and cisplatin was observed for the normal tissue. This finding suggests that CDDP-micells not only provide superior therapeutic efficacy but also reduce side effects caused by conventional cisplatin when combined with proton therapy.

  • Research Products

    (8 results)

All 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Improvement of energy stability of the Tohoku Dynamitron accelerator for microbeam and nanobeam application2013

    • Author(s)
      S. Matsuyama, M. Fujisawa, T. Nagaya, K. Ishii, A. Terakawa, et al.
    • Journal Title

      International Journal of PIXE

      Volume: Vol. 23 Nos. 1&2 Pages: 69-75

    • DOI

      10.1142/S0129083513400081

    • Peer Reviewed
  • [Journal Article] 腫瘍血流遮断により誘発されたマウス固形腫瘍内の元素分布2013

    • Author(s)
      寺川貴樹、石井慶造、松山成男, 他
    • Journal Title

      NMCC共同利用成果報告集

      Volume: 19 Pages: 230-235

  • [Journal Article] IMPROVEMEMT OF THE DETECTION EFFICIENCY OF THE IN-AIR SUBMILLI-PIXE CAMERA FOR BIOLOGICAL APPLICATION2012

    • Author(s)
      H. Sugai, K. Fujiki, K. Ishii, S. Matsuyama, A. Terakawa, et al.
    • Journal Title

      International Journal of PIXE

      Volume: Vol. 22 Nos. 1&2 Pages: 37-43

    • DOI

      10.1142/S0129083512400050

    • Peer Reviewed
  • [Journal Article] Preliminary Study of Proton Therapy Combined with Cisplatin2012

    • Author(s)
      A. TERAKAWA, K. ISHII, et al.
    • Journal Title

      CYRIC Annual Report

      Volume: 2010-2011 Pages: 46-48

  • [Presentation] PIXE分析法を用いた生体試料中の3次元元素分布画像取得法の開発2013

    • Author(s)
      松山哲生、石井慶造、寺川貴樹, 他
    • Organizer
      第29回PIXEシンポジウム
    • Place of Presentation
      若狭湾エネルギー研究センター
    • Year and Date
      20131113-15
  • [Presentation] PIXE分析用トレーサーへの量子ドットの応用に関する研究2013

    • Author(s)
      松山哲生、石井慶造、寺川貴樹, 他
    • Organizer
      日本原子力学会
    • Place of Presentation
      八戸工業大学
    • Year and Date
      20130903-05
  • [Presentation] Elemental analysis of a murine solid tumor treated with a vascular disrupting agent AVE80622013

    • Author(s)
      A. Terakawa, et al.
    • Organizer
      International conference on particle-induced X-ray emission (PIXE2013)
    • Place of Presentation
      ブラジルグラマド市
    • Year and Date
      20130303-08
  • [Presentation] PIXE分析法を用いたマウス固形腫瘍内のシスプラチン含有高分子ミセルの集積評価2012

    • Author(s)
      寺川貴樹、石井慶造、松山成男, 他
    • Organizer
      第18回NMCC共同利用成果発表会
    • Place of Presentation
      岩手医科大学
    • Year and Date
      20120511-12

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Published: 2015-06-25  

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