Effects of comprehensive rehabilitation in patients with non-alcoholic fatty liver disease (NAFLD)

2014 Fiscal Year Final Research Report

• Project/Area Number: 24650305
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tohoku University
• Principal Investigator: ITO Osamu 東北大学, 医学(系)研究科(研究院), 准教授 (00361072)
• Co-Investigator(Kenkyū-buntansha): MORI Nobuyoshi 東北大学, 大学院医学系研究科, 助教 (50464790) ; KOHZUKI Masahiro 東北大学, 大学院医学系研究科, 教授 (70234698)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: リハビリテーション / 内科 / 肝臓 / 脂質 / 肥満

Outline of Final Research Achievements

Non-alcoholic fatty liver disease (NAFLD) is a phenotype of metabolic syndrome. Paralleling the increasing prevalence of obesity, NAFLD becomes to be common and potentially serious all over the world. Thus, we examined effects of comprehensive rehabilitation in NAFLD. Seven adults (age 41.4±16.7 years, male/female 3/4), who were diagnosed NAFLD and resistant to regular outpatient treatment, were admitted. They underwent exercise therapy with a bicycle ergometer and an underwater treadmill and mild diet therapy of 1,600-1,200 kcal. After a guidance of life style modification, they were discharged and followed at home for 6 months. After the comprehensive rehabilitation, the BMI, serum AST and ALT were significantly decreased. These clinical courses indicate that the comprehensive rehabilitation has beneficial effects in NAFLD with obesity.

Free Research Field

リハビリテーション医学